Progesterone is a hormone that is normally secreted by the ovary after ovulation. It prepares the uterine lining for an embryo to implant. Low progesterone levels, also called a luteal phase defect, can lead to infertility or miscarriage.

Progesterone is often given after ovulation induction for intrauterine insemination, GIFT, or IVF. It can be given either by injection, vaginal suppository, or orally. Progesterone may be taken for 10 – 12 weeks of pregnancy.

The most common side effects include painful injections, and redness or rash. Occasionally mood swings occur. Your physician or nurse will discuss these and other risks associated with medication in detail before your treatment.